CVSS VectorNVD
CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:P/VC:N/VI:H/VA:L/SC:N/SI:N/SA:N
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4DescriptionNVD
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. When reading data encoded using the BYTE_ARRAY_LEN method, the cram_byte_array_len_decode() failed to validate that the amount of data being unpacked matched the size of the output buffer where it was to be stored. Depending on the data series being read, this could result either in a heap or a stack overflow with attacker-controlled bytes. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
AnalysisAI
HTSlib, a widely-used bioinformatics library for reading and writing sequence alignment formats, contains a critical buffer overflow vulnerability in its CRAM format decoder. The vulnerability exists in the cram_byte_array_len_decode() function which fails to validate that unpacked data matches the output buffer size, affecting HTSlib versions prior to 1.23.1, 1.22.2, and 1.21.1. …
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RemediationAI
Within 7 days: Identify all affected systems and apply vendor patches promptly. If patching is delayed, consider network segmentation to limit exposure.
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Vendor StatusVendor
Debian
| Release | Status | Fixed Version | Urgency |
|---|---|---|---|
| bullseye | vulnerable | 1.11-4 | - |
| bookworm | vulnerable | 1.16+ds-3 | - |
| trixie | vulnerable | 1.21+ds-1 | - |
| forky, sid | vulnerable | 1.22.1+ds2-1 | - |
| (unstable) | fixed | (unfixed) | - |
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External POC / Exploit Code
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EUVD-2026-12948