EUVD-2026-12958CVSS Vector
CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:N/VI:L/VA:L/SC:N/SI:N/SA:N
Lifecycle Timeline
3Description
SAMtools is a program for reading, manipulating and writing bioinformatics file formats. Starting in version 1.17, in the cram-size command, used to write information about how well CRAM files are compressed, a check to see if the `cram_decode_compression_header()` was missing. If the function returned an error, this could lead to a NULL pointer dereference. Exploiting this bug causes a NULL pointer dereference. Typically this will cause the program to crash. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
Analysis
SAMtools versions 1.17 and later contain a null pointer dereference vulnerability in the cram-size command due to missing error handling for the cram_decode_compression_header() function. When this function fails and returns an error, the code does not properly validate the return value before dereferencing the pointer, allowing an attacker to crash the application by providing a malformed CRAM file. …
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Remediation
Within 30 days: Identify affected systems and apply vendor patches as part of regular patch cycle. Monitor vendor channels for patch availability.
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