CVSS Vector
CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:L/VI:N/VA:L/SC:N/SI:N/SA:N
Lifecycle Timeline
4Description
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. In the `cram_decode_slice()` function called while reading CRAM records, validation of the reference id field occurred too late, allowing two out of bounds reads to occur before the invalid data was detected. The bug does allow two values to be leaked to the caller, however as the function reports an error it may be difficult to exploit them. It is also possible that the program will crash due to trying to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
Analysis
HTSlib contains an out-of-bounds read vulnerability in the cram_decode_slice() function that fails to validate the reference ID field early enough during CRAM file parsing, allowing two separate out-of-bounds reads before error detection. The vulnerability affects HTSlib versions prior to 1.23.1, 1.22.2, and 1.21.1, and can result in information disclosure through leaked memory values or application crashes when processing malicious or corrupted CRAM bioinformatics files. …
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Remediation
Within 30 days: Identify affected systems and apply vendor patches as part of regular patch cycle. Monitor vendor channels for patch availability.
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Priority Score
Vendor Status
Debian
| Release | Status | Fixed Version | Urgency |
|---|---|---|---|
| bullseye | vulnerable | 1.11-4 | - |
| bookworm | vulnerable | 1.16+ds-3 | - |
| trixie | vulnerable | 1.21+ds-1 | - |
| forky, sid | vulnerable | 1.22.1+ds2-1 | - |
| (unstable) | fixed | (unfixed) | - |
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External POC / Exploit Code
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EUVD-2026-12934